ANTIHYPERCHOLESTEROLEMIC POTENTIAL OF CORIANDER (Coriandrum sativum L) EXTRACT

Abstract

One of the risk factors of atherosclerosis is dyslipidemia. In Indonesia, the prevalence
rate of dyslipidemia is increasing, until 2018 there were cases of elevated cholesterol
level 43%, elevated triglyceride 26%, elevated LDL 83%, and reduced HDL 23%.
Therapeutic management of dyslipidemia patients with medicine is not affordable for
all societies, and it has adverse effects. Therefore, a study of the use of Indonesian
traditional medicinal plants is necessary. The purpose of this research was to observe
the effects of coriander extract to lower blood cholesterol level in mice. This study
used male Swiss Webster mice divided into 3 groups, and each group consisted of 5
male Swiss Webster mice, those were a group of negative control with distilled water,
a control group with oral treatment of coriander extract with a dosage of 840 mg/kg
BW and a group of positive control with simvastatin with a dosage of 1.3 mg/kg BW.
Fasting cholesterol test was performed with CHOD-PAP method on day 0 before high
fat diet induction and propylthiouracil on day 30-40 after induction, and 7 days after
administering coriander ethanol extract.  The average reduction of cholesterol level
in each group was 9.8 mg/dL (negative control), 39.4 mg/dL (dosage of 840 mg/kg
BW) and 63.6 md/dL (positive control). The result of one way analysis of variance
(anova) showed a significant difference in the reduction of cholesterol level of each
group, that is p=0.000 (p< 0.005). In conclusion, coriander (Coriandrum sativum L.)
extract can lower cholesterol level in male Swiss Webster mice.  
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Keywords: coriander, antihypercholesterolemia, mice, dyslipidemia