Correlation between HbA1C and Serum Creatinine Levels of Javanese Ethnicity Type 2 Diabetes Mellitus Patients

Abstract

Javanese people had genetic polymorphisms that made them susceptible to type 2 diabetes mellitus. The complication of diabetes was diabetic nephropathy, the most common etiology of end-stage renal disease. Hyperglycemia could interfere with the glomerular filtration and cause an increase in serum creatinine. HbA1c test and serum creatinine were used to monitor diabetes patients. This research analyzed the correlation between HbA1c and serum creatinine in Javanese ethnicity type 2 DM patients.
It was observational analytic research using the cross-sectional approach. The subject were 36 Javanese type 2 DM patients at Pandanaran, Gunungpati, and Purwoyoso Community Health Center. The primary data was obtained through a questionnaire. HbA1c and serum creatinine were from the medical record. The analysis was Spearman's correlation test, which showed significance if p<0,05. The average age of the subject was 59,67±5,5 years and most of them had hypertension (69,4%). The average level of HbA1c was above normal (8,04±2,09%), while the serum creatinine level was normal (0,79±0,31 mg/dL). There was no significant correlation between HbA1c and serum creatinine levels (p=0,228; r=0,206).
HbA1c as the glycemic control parameter of DM patients was not correlated to the serum creatinine as the renal function parameter.

Keywords : Type 2 diabetes mellitus, HbA1c, glycemic control, serum creatinine